Genes V by Benjamin Lewin

Introduction: Cells as macromolecular assemblies. 1. Cells obey the laws of physics and chemistry. 2. Cells are organized into compartments --
pt. 1. DNA as a store of information. 3. Genes are mutable units. 4. DNA is the genetic material. 5. The topology of nucleic acids. 6. Isolating the gene --
pt. 2. Translation: expressing genes as proteins. 7. The assembly line for protein synthesis. 8. Transfer RNA is the translational adaptor. 9. Ribosomes provide a translation factory. 10. Messenger RNA is the template --
pt. 3. Constructing the cell. 11. The apparatus for protein localization. 12. Receptors and signal transduction: channels and ion uptake. 13. Cell cycle and growth regulation --
pt. 4. Control of prokaryotic gene expression. 14. Control at initiation: RNA polymerase-promoter interactions. 15. A panoply of operons: the lactose paradigm and others. 16. Control of RNA structure: termination and antitermination. 17. Phage strategies: lytic cascades and lysogenic repression. pt. 5. Perpetuation of DNA. 18. The replicon: unit of replication. 19. Primosomes and replisomes: the apparatus for DNA replication. 20. Systems that safeguard DNA --
pt. 6. Organization of the eukaryotic genome. 21. The extraordinary power of DNA technology. 22. Genome size and genetic content. 23. The eukaryotic gene: conserved exons and unique introns. 24. Gene numbers: repetition and redundancy. 25. Genomes sequestered in organelles. 26. Organization of simple sequence DNA. 27. The genome is packaged into chromosomes. 28. Chromosomes consist of nucleosomes --
pt. 7. Eukaryotic transcription and RNA processing. 29. Building the transcription complex: promoters, factors, and RNA polymerases. 30. Regulation of transcription: factors that activate the basal apparatus. 31. The apparatus for nuclear splicing. 32. RNA as catalyst: changing the informational content of RNA --
pt. 8. The dynamic genome: DNA in flux. 33. Recombination of DNA. 34. Transposons that mobilize via DNA. 35. Retroviruses and retroposons. 36. Rearrangement and amplification in the genome --
pt. 9. Genes in development. 37. Generation of immune diversity by gene reorganization. 38. Gene regulation in development: gradients and cascades. 39. Oncogenes: gene expression and cancer --
Epilogue: Landmark shifts in perspectives